A lateralized model of the pain-depression dyad

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:127

Review

Maallo, Anne Margarette S.¹  Moulton, Eric A.^1,2  Sieberg, Christine B.^1,3,4  Giddon, Donald B.^5,6  Borsook, David^7,8,9  Holmes, Scott A.¹ 

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Ctr Pain & Brain, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Ophthalmol, Boston Childrens Hosp, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston Childrens Hosp, Dept Psychiat & Behav Sci, Biobehav Pediat Pain Lab, Boston, MA 02115 USA

[4] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[5] Harvard Univ, Harvard Sch Dent Med, Boston, MA USA

[6] Brigham & Womens Hosp, Pain Management Ctr, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA

[7] Harvard Med Sch, Boston, MA 02115 USA

[8] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA

[9] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02115 USA

关键词: Pain;    Nociception;    Depression;    Lateralization;   

DOI  :  10.1016/j.neubiorev.2021.06.003

来源: Elsevier

【 摘 要 】

Chronic pain and depression are two frequently co-occurring and debilitating conditions. Even though the former is treated as a physical affliction, and the latter as a mental illness, both disorders closely share neural substrates. Here, we review the association of pain with depression, especially when symptoms are lateralized on either side of the body. We also explore the overlapping regions in the forebrain implicated in these conditions. Finally, we synthesize these findings into a model, which addresses gaps in our understanding of comorbid pain and depression. Our lateralized pain-depression dyad model suggests that individuals diagnosed with depression should be closely monitored for pain symptoms in the left hemibody. Conversely, for patients in pain, with the exception of acute pain with a known source, referrals in today's pain centers for psychological evaluation should be part of standard practice, within the framework of an interdisciplinary approach to pain treatment.

【 授权许可】

Free