The cue-reactivity paradigm: An ensemble of networks driving attention and cognition when viewing drug and natural reward-related stimuli

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:130

Article

Hill-Bowen, Lauren D.¹  Riedel, Michael C.²  Poudel, Ranjita¹  Salo, Taylor¹  Flannery, Jessica S.¹  Camilleri, Julia A.^3,4  Eickhoff, Simon B.^3,4  Laird, Angela R.²  Sutherland, Matthew T.¹ 

[1] Florida Int Univ, Dept Psychol, AHC-4,RM 312,11200 SW 8th St, Miami, FL 33199 USA

[2] Florida Int Univ, Dept Phys, 11200 SW 8th St, Miami, FL 33199 USA

[3] Res Ctr Julich, Inst Neurosci & Med, Brain & Behav INM 7, D-52425 Julich, Germany

[4] Heinrich Heine Univ Dusseldorf, Med Fac, Inst Syst Neurosci, D-40225 Dusseldorf, Germany

关键词: cue-reactivity;    drug craving;    functional connectivity;    hierarchical clustering;    meta-analytical connectivity modeling;    posterior cingulate cortex;   

DOI  :  10.1016/j.neubiorev.2021.08.010

来源: Elsevier

【 摘 要 】

The cue-reactivity paradigm is a widely adopted neuroimaging probe engendering brain activity linked with attentional, affective, and reward processes following presentation of appetitive stimuli. Given the multiple mental operations invoked, we sought to decompose cue-related brain activity into constituent components employing emergent meta-analytic techniques when considering drug and natural reward-related cues. We conducted coordinate-based meta-analyses delineating common and distinct brain activity convergence across cue-reactivity studies (N = 196 articles) involving drug (n = 133) or natural (n = 63) visual stimuli. Across all studies, convergence was observed in limbic, cingulate, insula, and fronto-parieto-occipital regions. Drug-distinct convergence was observed in posterior cingulate, dorsolateral prefrontal, and temporo-parietal regions, whereas distinct-natural convergence was observed in thalamic, insular, orbitofrontal, and occipital regions. We characterized connectivity profiles of identified regions by leveraging task-independent and task-dependent MRI datasets, grouped these profiles into subnetworks, and linked each with putative mental operations. Outcomes suggest multifaceted brain activity during cue-reactivity can be decomposed into elemental processes and indicate that while drugs of abuse usurp the brain's natural-reward-processing system, some regions appear distinct to drug cue-reactivity.

【 授权许可】

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