Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:37

Editorial Material

Moore, Holly^1,2  Geyer, Mark A.^3,4  Carter, Cameron S.^5,6,7  Barch, Deanna M.^8,9,10 

[1] Columbia Univ, Dept Psychiat, New York, NY 10027 USA

[2] New York State Psychiat Inst & Hosp, Dept Integrat Neurosci, New York, NY 10032 USA

[3] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[4] VA San Diego Healthcare Syst, Res Serv, San Diego, CA USA

[5] Univ Calif Davis, Ctr Neurosci, Sacramento, CA 95817 USA

[6] Univ Calif Davis, Dept Psychiat, Sacramento, CA 95817 USA

[7] Univ Calif Davis, Dept Psychol, Sacramento, CA 95817 USA

[8] Washington Univ, Dept Psychol, St Louis, MO 63130 USA

[9] Washington Univ, Dept Psychiat, St Louis, MO USA

[10] Washington Univ, Dept Radiol, St Louis, MO USA

关键词: Psychosis;    Psychopharmacology;    Behavior;    Rat;    Mouse;    Non-human primate;   

DOI  :  10.1016/j.neubiorev.2013.09.011

来源: Elsevier

【 摘 要 】

Over the past two decades, the awareness of the disabling and treatment-refractory effects of impaired cognition in schizophrenia has increased dramatically. In response to this still unmet need in the treatment of schizophrenia, the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative was developed. The goal of CNTRICS is to harness cognitive neuroscience to develop a brain-based set of tools for measuring cognition in schizophrenia and to test new treatments. CNTRICS meetings focused on development of tasks with cognitive construct validity for use in both human and animal model studies. This special issue presents papers discussing the cognitive testing paradigms selected by CNTRICS for animal model systems. These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free