The brain norepinephrine system, stress and cardiovascular vulnerability

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:74

Article

Wood, Susan K.¹  Valentino, Rita J.^2,3 

[1] Univ South Carolina, Dept Pharmacol Physiol & Neurosci, Sch Med, Columbia, SC 29209 USA

[2] Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

关键词: Locus coeruleus;    Norepinephrine;    Social defeat;    Coping;    Cardiovascular disease;    Susceptibility;    Individual differences;   

DOI  :  10.1016/j.neubiorev.2016.04.018

来源: Elsevier

【 摘 要 】

Chronic exposure to psychosocial stress has adverse effects on cardiovascular health, however the stress-sensitive neurocircuitry involved remains to be elucidated. The anatomical and physiological characteristics of the locus coeruleus (LC)-norepinephrine (NE) system position it to contribute to stress induced cardiovascular disease. This review focuses on cardiovascular dysfunction produced by social stress and a major theme highlighted is that differences in coping strategy determine individual differences in social stress-induced cardiovascular vulnerability. The establishment of different coping strategies and cardiovascular vulnerability during repeated social stress has recently been shown to parallel a unique plasticity in LC afferent regulation, resulting in either excitatory or inhibitory input to the LC. This contrasting regulation of the LC would translate to differences in cardiovascular regulation and may serve as the basis for individual differences in the cardiopathological consequences of social stress. The advances described suggest new directions for developing treatments and/or strategies for decreasing stress-induced cardiovascular vulnerability. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free