Brain alterations in children/adolescents with ADHD revisited: A neuroimaging meta-analysis of 96 structural and functional studies

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:100

Review

Samea, Fateme¹  Soluki, Solmaz¹  Nejati, Vahid^1,2  Zarei, Mojtaba³  Cortese, Samuele^4,5,6,7  Eickhoff, Simon B.^8,9  Tahmasian, Masoud³  Eickhoff, Claudia R.^9,10,11 

[1] Shahid Beheshti Univ, Inst Cognit & Brain Sci, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Psychol, Tehran, Iran

[3] Shahid Beheshti Univ, Inst Med Sci & Technol, Daneshjou Blvd,POB 1983969411, Tehran, Iran

[4] Univ Southampton, Acad Unit Psychol, Ctr Innovat Mental Hlth, Southampton, Hants, England

[5] Univ Southampton, Fac Med, Clin & Expt Sci CNS & Psychiat, Southampton, Hants, England

[6] Univ Nottingham, Sch Med, Div Psychiat & Appl Psychol, Nottingham, England

[7] NYU, Langone Med Ctr, Dept Child & Adolescent Psychiat, New York, NY USA

[8] Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, Fac Med, Dusseldorf, Germany

[9] Res Ctr Julich, Inst Neurosci & Med INM 1, INM 7, Julich, Germany

[10] Heinrich Heine Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany

[11] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

关键词: ADHD;    Activation likelihood estimation;    Coordinate-based meta-analysis;    fMRI;    VBM;   

DOI  :  10.1016/j.neubiorev.2019.02.011

来源: Elsevier

【 摘 要 】

The findings of neuroimaging studies in children/adolescents with ADHD, and even those of previous meta-analyses, are divergent. Here, Activation Likelihood Estimation meta-analysis, following the current best-practice guidelines, was conducted. We searched multiple databases and traced the references up to June 2018. Then, we extracted the reported coordinates reflecting group comparison between ADHD and healthy subjects from 96 eligible studies, containing 1914 unique participants. The analysis of pooled structural and functional, sub-analyses restricted to modality, and in-/decreased contrast did not yield any significant findings. However, further sub-analyses in the task-fMRI experiments (neutral stimuli only) led to aberrant activity in the left pallidum/putamen and decreased activity (male subjects only) in the left inferior frontal gyrus. The overall findings indicate a lack of regional convergence in children/adolescents with ADHD, which might be due to heterogeneous clinical populations, various experimental design, preprocessing, statistical procedures in individual publications. Our results highlight the need for further high-powered investigations, but may also indicate ADHD pathophysiology might rest in network interactions rather than just regional abnormality.

【 授权许可】

Free