Can cocaine-induced neuroinflammation explain maladaptive cocaine-associated memories?

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:111

Review

Correia, Caroline¹  Romieu, Pascal¹  Olmstead, Mary C.²  Befort, Katia¹ 

[1] Univ Strasbourg, Fac Psychol, Ctr Rech Natl Sci, LNCA,UMR 7364, 12 Rue Goethe, F-67000 Strasbourg, France

[2] Queens Univ, Ctr Neurosci Studies, Dept Psychol, Kingston, ON K7L 3N6, Canada

关键词: Cocaine;    Addiction;    Neuroinflammation;    Reconsolidation;    Memory;   

DOI  :  10.1016/j.neubiorev.2020.01.001

来源: Elsevier

【 摘 要 】

Persistent and intrusive memories define a number of psychiatric disorders, including posttraumatic stress disorder and substance use disorder. In the latter, memory for drug-paired cues plays a critical role in sustaining compulsive drug use as these are potent triggers of relapse. As with many drugs, cocaine-cue associated memory is strengthened across presentations as cues become reliable predictors of drug availability. Recently, the targeting of cocaine-associated memory through disruption of the reconsolidation process has emerged as a potential therapeutic strategy; reconsolidation reflects the active process by which memory is re-stabilized after retrieval. In addition, a separate line of work reveals that neuroinflammatory markers, regulated by cocaine intake, play a role in memory processes. Our review brings these two literatures together by summarizing recent findings on cocaine-associated reconsolidation and cocaine-induced neuroinflammation. We discuss the interactions between reconsolidation processes and neuroinflammation following cocaine use, concluding with a new perspective on treatment to decrease risk of relapse to cocaine use.

【 授权许可】

Free