Fetal programming of schizophrenia: Select mechanisms

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:49

Review

Debnath, Monojit¹  Venkatasubramanian, Ganesan^2,3  Berk, Michael^4,5 

[1] Natl Inst Mental Hlth & Neurosci, Dept Human Genet, Bangalore 560029, Karnataka, India

[2] Natl Inst Mental Hlth & Neurosci, Neurobiol Res Ctr, Translat Psychiat Lab, Bangalore 560029, Karnataka, India

[3] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bangalore 560029, Karnataka, India

[4] Deakin Univ, Sch Med, Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic 3217, Australia

[5] Univ Melbourne, Dept Psychiat, Florey Inst Neurosci & Mental Hlth & Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic 3052, Australia

关键词: Schizophrenia;    Fetal programming;    Prenatal;    Perinatal;    Stress;    Infection;    Diet;    Inflammation;    Oxidative stress;    Neurodevelopment;    Epigenetics;   

DOI  :  10.1016/j.neubiorev.2014.12.003

来源: Elsevier

【 摘 要 】

Mounting evidence indicates that schizophrenia is associated with adverse intrauterine experiences. An adverse or suboptimal fetal environment can cause irreversible changes in brain that can subsequently exert long-lasting effects through resetting a diverse array of biological systems including endocrine, immune and nervous. It is evident from animal and imaging studies that subtle variations in the intrauterine environment can cause recognizable differences in brain structure and cognitive functions in the offspring. A wide variety of environmental factors may play a role in precipitating the emergent developmental dysregulation and the consequent evolution of psychiatric traits in early adulthood by inducing inflammatory, oxidative and nitrosative stress (IO&NS) pathways, mitochondrial dysfunction, apoptosis, and epigenetic dysregulation. However, the precise mechanisms behind such relationships and the specificity of the risk factors for schizophrenia remain exploratory. Considering the paucity of knowledge on fetal programming of schizophrenia, it is timely to consolidate the recent advances in the field and put forward an integrated overview of the mechanisms associated with fetal origin of schizophrenia. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free