Oxytocin pathways in the intergenerational transmission of maternal early life stress

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:73

Review

Toepfer, Philipp¹  Heim, Christine^1,2  Entringer, Sonja^1,3  Binder, Elisabeth^4,5  Wadhwa, Pathik³  Buss, Claudia^1,3 

[1] Charite, Inst Med Psychol, Luisenstr 57, D-10117 Berlin, Germany

[2] Penn State Univ, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA

[3] UC Irvine, Dev Hlth & Dis Res Program, 333 City Blvd W,Suite 810, Orange, CA 92868 USA

[4] Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany

[5] Emory Univ, Dept Psychiat & Behav Sci, Sch Med, Atlanta, GA 30307 USA

关键词: Development;    Depression;    Early life stress;    Epigenetics;    Gene-environment interactions;    Intergenerational transmission;    Mother-child;    Oxytocin;    Parenting behavior;   

DOI  :  10.1016/j.neubiorev.2016.12.026

来源: Elsevier

【 摘 要 】

Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by EIS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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