Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:127

Review

Sumsuzzman, Dewan Md.^1,2,3,4  Choi, Jeonghyun^1,2,3,4  Jin, Yunho^2,3,4  Hong, Yonggeun^1,2,3,4,5 

[1] Inje Univ, Grad Sch, Dept Rehabil Sci, 197 Inje Ro, Gimhae 50834, Gyeongsangnam D, South Korea

[2] Inje Univ, Biohlth Prod Res Ctr BPRC, Gimhae 50834, South Korea

[3] Inje Univ, Ubiquitous Healthcare & Antiaging Res Ctr uHARC, Gimhae 50834, South Korea

[4] Coll Healthcare Med Sci & Engn, Dept Phys Therapy, Gimhae 50834, South Korea

[5] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

关键词: Melatonin;    Cognition;    Alsheimer's disease;    Insomnia;    Healthy-subjects;    Systematic review;    Meta-analysis;   

DOI  :  10.1016/j.neubiorev.2021.04.034

来源: Elsevier

【 摘 要 】

Endogenous melatonin levels are inversely associated with age and cognitive deficits. Although melatonin can improve psychopathological behavior disturbances in clinical trials, whether melatonin may also enhance cognitive function remains elusive. This study examined cognitive outcomes from randomized trials of melatonin treatment for Alzheimer's disease (AD), insomnia, and healthy-subjects. Twenty-two studies met the inclusion criteria (AD = 9, insomnia = 2, healthy-subjects = 11). AD patients receiving 12 weeks of melatonin treatment improved mini-mental state examination (MMSE) score [MD: 1.82 (1.01; 2.63) p < 0.0001]. Importantly, melatonin significantly improved MMSE score in mild stage of AD [MD: 1.89 (0.96; 2.82) p < 0.0001]. In healthy-subjects, although daytime melatonin treatment notably decreased in accuracy by correct responses [SMD:-0.74 (-1.03;-0.45) p < 0.00001], the reaction-time score on different stimuli (p = 0.37) did not increased. Additionally, by pooling of short-term, spatial, and visual memory scores, melatonin did not reduce memory function (p = 0.08). Meta-analysis of MMSE score suggested that melatonin is effective in treatment for mild stage of AD. Additionally, we propose that melatonin may be preferable to traditional hypnotics in management of insomnia.

【 授权许可】

Free