Inflammation and the two-hit hypothesis of schizophrenia

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:38

Review

Feigenson, Keith A.¹  Kusnecov, Alex W.^2,3  Silverstein, Steven M.^1,4 

[1] Rutgers State Univ, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Psychol, Behav & Syst Neurosci Program, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Joint Grad Program Toxicol, Piscataway, NJ 08854 USA

[4] Rutgers State Univ, Univ Behav Hlth Care Rutgers, Piscataway, NJ 08855 USA

关键词: Schizophrenia;    Inflammation;    Infection;    Biomarkers;    Comorbidity;    Animal Models;   

DOI  :  10.1016/j.neubiorev.2013.11.006

来源: Elsevier

【 摘 要 】

The high societal and individual cost of schizophrenia necessitates finding better, more effective treatment, diagnosis, and prevention strategies. One of the obstacles in this endeavor is the diverse set of etiologies that comprises schizophrenia. A substantial body of evidence has grown over the last few decades to suggest that schizophrenia is a heterogeneous syndrome with overlapping symptoms and etiologies. At the same time, an increasing number of clinical, epidemiological, and experimental studies have shown links between schizophrenia and inflammatory conditions. In this review, we analyze the literature on inflammation and schizophrenia, with a particular focus on comorbidity, biomarkers, and environmental insults. We then identify several mechanisms by which inflammation could influence the development of schizophrenia via the two-hit hypothesis. Lastly, we note the relevance of these findings to clinical applications in the diagnosis, prevention, and treatment of schizophrenia. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free