Meta-analysis of molecular imaging of serotonin transporters in ecstasy/polydrug users

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:63

Review

Roberts, Carl. Alexander¹  Jones, Andrew¹  Montgomery, Catharine² 

[1] Univ Liverpool, Dept Psychol Sci, Liverpool L69 7Z, Merseyside, England

[2] Liverpool John Moores Univ, Sch Nat Sci & Psychol, Liverpool L3 5UX, Merseyside, England

关键词: Ecstasy;    MDMA;    Serotonin;    SERT;    PET;    SPECT;    Meta-analysis;    Molecular imaging;   

DOI  :  10.1016/j.neubiorev.2016.02.003

来源: Elsevier

【 摘 要 】

We conducted a meta-analysis on the available data from studies investigating SERTs in ecstasy users and polydrug using controls. From 7 studies we compared data from 157 ecstasy users and 148 controls across 14 brain regions. The main effect suggested ecstasy/MDMA related SERT reductions (SMD = 0.52, 95% Cis [0.40, 0.65]; Z= 8.36,p <.01, I-2 = 89%). A significant effect of subgroups (X-2 =37.41, df = 13,p<.01,I-2 = 65.3%) suggested differential effects across brain ROIs. Ecstasy users showed significant SERT reductions in 11 out of the 14 regions, including every neocortical and limbic region analysed. Greatest effects were observed in the occipital cortex (SMD = 1.09, 95% Cis [0.70, 1.48]). No group effects were observed in subcortical areas of the caudate, putamen and midbrain. Literature on Postsynaptic 5HT2A receptor imaging was synthesised with these results. We conclude that, in line with preclinical data, serotonin axons with the longest projections from the raphe nuclei appear to be most affected by ecstasy/MDMA use. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

【 授权许可】

Free