Understanding epigenetic architecture of suicide neurobiology: A critical perspective

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:72

Review

Roy, Bhaskar¹  Dwivedi, Yogesh¹ 

[1] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA

关键词: Suicide;    Epigenetics;    DNA methylation;    Histone modification;    Gene expression;   

DOI  :  10.1016/j.neubiorev.2016.10.031

来源: Elsevier

【 摘 要 】

Current understanding of environmental cross-talk with genetic makeup is found to be mediated through an epigenetic interface which is associated with prominent reversible and heritable changes at gene expression level. Recent emergence of epigenetic modulation in shaping the genetic information has become a key regulatory factor in answering the underlying complexities associated with several mental disorders. A comprehensive understanding of the pertinent changes in the epigenetic makeup of suicide phenotype exhibits a characteristic signature with the possibility of using it as a biomarker to help predict the risk factors associated with suicide. Within the scope of this current review, the most sought after epigenetic changes of DNA methylation and histone modification are thoroughly scrutinized to understand their close functional association with the broad spectrum of suicide phenotype. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free