The brain map of gait variability in aging, cognitive impairment and dementia A systematic review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:74

Review

Tian, Qu¹  Chastan, Nathalie^1,2,3  Bair, Woei-Nan¹  Resnick, Susan M.⁴  Ferrucci, Luigi¹  Studenski, Stephanie A.¹ 

[1] NIA, Longitudinal Studies Sect, Translat Gerontol Branch, 251 Bayview Blvd,Suite 100, Baltimore, MD 21224 USA

[2] Rouen Univ Hosp, Dept Neurophysiol, 1 Rue Germont, F-76000 Rouen, France

[3] Normandy Univ, COMETE, INSERM U1075, F-14032 Caen, France

[4] NIA, Lab Behav Neurosci, 251 Bayview Blvd,Suite 100, Baltimore, MD 21224 USA

关键词: Gait variability;    Neuroimaging;    Older adults;    Aging;    Cognitive impairment;    Dementia;   

DOI  :  10.1016/j.neubiorev.2017.01.020

来源: Elsevier

【 摘 要 】

While gait variability may reflect subtle changes due to aging or cognitive impairment (CI), associated brain characteristics remain unclear. We summarize structural and functional neuroimaging findings associated with gait variability in older adults with and without CI and dementia. We identified 17 eligible studies; all were cross-sectional; few examined multiple brain areas. In older adults, temporal gait variability was associated with structural differences in medial areas important for lower limb coordination and balance. Both temporal and spatial gait variability were associated with structural and functional differences in hippocampus and primary sensorimotor cortex and structural differences in anterior cingulate cortex, basal ganglia, association tracts, and posterior thalamic radiation. In CI or dementia, some associations were found in primary motor cortex, hippocampus, prefrontal cortex and basal ganglia. In older adults, gait variability may be associated with areas important for sensorimotor integration and coordination. To comprehend the neural basis of gait variability with aging and Cl, longitudinal studies of multiple brain areas are needed. Published by Elsevier Ltd.

【 授权许可】

Free