The neuroscience of sadness: A multidisciplinary synthesis and collaborative review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:111

Review

Arias, Juan A.^1,2  Williams, Claire¹  Raghvani, Rashmi¹  Aghajani, Moji³  Baez, Sandra⁴  Belzung, Catherine⁵  Booij, Linda^6,7  Busatto, Geraldo⁸  Chiarella, Julian^6,7  Fu, Cynthia H. Y.^9,10  Ibanez, Agustin^{11,12,13,14,15}  Liddell, Belinda J.¹⁶  Lowe, Leroy¹⁷  Penninx, Brenda W. J. H.³  Rosa, Pedro⁸  Kemp, Andrew H.^1,8,18,19 

[1] Swansea Univ, Dept Psychol, Singleton Campus, Swansea SA2 8PP, W Glam, Wales

[2] Univ Santiago de Compostela, Dept Stat Math Anal & Operat Res, Santiago De Compostela, Spain

[3] Amsterdam UMC, Dept Psychiat, Locat VUMC, GGZ InGeest Res & Innovat,Amsterdam Neurosci, Amsterdam, Netherlands

[4] Univ Los Andes, Bogota, Colombia

[5] Univ Tours, INSERM, iBrain, UMR 1253, Tours, France

[6] Concordia Univ Montreal, Dept Psychol, Montreal, PQ, Canada

[7] Univ Montreal, CHU St Justine, Montreal, PQ, Canada

[8] Univ Sao Paulo, Dept Psychiat, Sao Paulo, Brazil

[9] Univ East London, Sch Psychol, London, England

[10] Kings Coll London, Ctr Affect Disorders, Inst Psychiat Psychol & Neurosci, London, England

[11] Favaloro Univ, INECO Fdn, Inst Cognit & Translat Neurosci INCYT, Buenos Aires, DF, Argentina

[12] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF, Argentina

[13] Univ Adolfo Ibanez, CSCN, Sch Psychol, Santiago, Chile

[14] Univ Autonoma Caribe, Barranquilla, Colombia

[15] Australian Res Council, Ctr Excellence Cognit & Its Disorders, Sydney, NSW, Australia

[16] Univ New South Wales, Sch Psychol, Kensington, NSW, Australia

[17] Neuroqualia NGO, Turo, NS, Canada

[18] Univ Sydney, Discipline Psychiat, Sydney, NSW, Australia

[19] Univ Sydney, Sch Psychol, Sydney, NSW, Australia

关键词: Sadness;    Major depressive disorder;    Basic emotions;    Psychological constructionism;    Genetics;    Psychophysiology;    Neuroimaging;    Affective neuroscience;    Heart rate variability;    GENIAL model;    Health and wellbeing;    Vagal function;   

DOI  :  10.1016/j.neubiorev.2020.01.006

来源: Elsevier

【 摘 要 】

Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies - including meta-analyses - indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may - in part - contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy.

【 授权许可】

Free