Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:92

Review

Arnone, Danilo^3,4  Saraykar, Smita¹  Salem, Haitham¹  Teixeira, Antonio L.¹  Dantzer, Robert²  Selvaraj, Sudhakar^1,2 

[1] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, 1515 Holcombe Blvd,Unit 1450, Houston, TX 77030 USA

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Affect Disorders, Dept Psychol Med, London, England

[4] South London & Maudsley NHS Fdn Trust, London, England

关键词: Kynurenine;    Mood disorder;    Depression;    Bipolar disorder;    Tryptophan;    Inflammation;    Quinolinic acid;   

DOI  :  10.1016/j.neubiorev.2018.05.031

来源: Elsevier

【 摘 要 】

Activation of the kynurenine pathway is one of the described mechanisms by which inflammation can induce depression. It involves multiple pathways including interference with the bioavailability of tryptophan central to the synthesis of the neurotransmitter serotonin. In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ratio of kynurenine and tryptophan) and mood disorders by conducting a meta-analysis. Fifty-six studies were identified, 21 met inclusion criteria and 14 were deemed suitable (9 investigating unipolar depression and 5 bipolar disorder). We found decreased levels of kynurenine in unipolar major depression vs. healthy controls but studies were significantly heterogeneous in nature. No significant differences were found in tryptophan levels or kynurenine/tryptophan ratios. Kynurenine metabolites are likely to play a role in major depression but an exact etiological role in mood disorder seem complex and requires further research.

【 授权许可】

Free