The association of the BDNF Va166Met polymorphism and the hippocampal volumes in healthy humans: A joint meta-analysis of published and new data

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:42

Review

Harrisberger, F.^1,2  Spalek, K.³  Smieskova, R.^1,2  Schmidt, A.^1,2  Coynel, D.^3,4  Milnik, A.⁴  Fastenrath, M.³  Freytag, V.⁴  Gschwind, L.³  Walter, A.¹  Vogel, T.¹  Bendfeldt, K.²  de Quervain, D. J. -F.^1,3  Papassotiropoulos, A.^1,4,5  Borgwardt, S.^1,2,6 

[1] Univ Basel, Dept Psychiat UPK, CH-4056 Basel, Switzerland

[2] Univ Basel Hosp, Med Image Anal Ctr, CH-4031 Basel, Switzerland

[3] Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland

[4] Univ Basel, Dept Psychol, Div Mol Neurosci, CH-4055 Basel, Switzerland

[5] Univ Basel, Dept Biozentrum, Life Sci Training Facil, CH-4056 Basel, Switzerland

[6] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London SE5 8AF, England

关键词: BDNF Va166Met;    rs6265;    Brain-derived neurotrophic factor;    BDNF;    MRI;    Hippocampus;    sMRI;    Structural;   

DOI  :  10.1016/j.neubiorev.2014.03.011

来源: Elsevier

【 摘 要 】

Background: The brain-derived neurotrophic factor (BDNF) Va166Met polymorphism (refSNP Cluster Report: rs6265) is a common and functionally relevant single nucleotide polymorphism (SNP). The gene itself, as well as the SNP rs6265, have been implicated in hippocampal learning and memory. However, imaging genetic studies have produced controversial results about the impact of this SNP on hippocampal volumes in healthy subjects. Methods: We examined the association between the rs6265 polymorphism and hippocampal volume in 643 healthy young subjects using automatic segmentation and subsequently included these data in a meta-analysis based on published studies with 5298 healthy subjects in total. Results: We found no significant association between SNP rs6265 and hippocampal volumes in our sample (g= 0.05, p =0.58). The meta-analysis revealed a small, albeit significant difference in hippocampal volumes between genotype groups, such that Met-carriers had slightly smaller hippocampal volumes than Val/Val homozygotes (g=0.09, p=0.04), an association that was only evident when manual (g=0.22, p = 0.01) but not automatic tracing approaches (g=0.04, p = 0.38) were used. Studies using manual tracing showed evidence for publication bias and a significant decrease in effect size over the years with increasing sample sizes. Conclusions: This study does not support the association between SNP rs6265 and hippocampal volume in healthy individuals. The weakly significant effect observed in the meta-analysis is mainly driven by studies with small sample sizes. In contrast, our original data and the meta-analysis of automatically segmented hippocampal volumes, which was based on studies with large samples sizes, revealed no significant genotype effect. Thus, meta-analyses of the association between rs6265 and hippocampal volumes should consider possible biases related to measuring technique and sample size. (C) 2014 The Authors. Published by Elsevier Ltd.

【 授权许可】

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