Updating and characterizing neuroanatomical markers in high-risk subjects, recently diagnosed and chronic patients with schizophrenia: A revised coordinate-based meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:123

Review

Liloia, Donato^1,2,3  Brasso, Claudio⁴  Cauda, Franco^1,2,3,5  Mancuso, Lorenzo^1,2,3  Nani, Andrea^1,2,3  Manuello, Jordi^1,2,3  Costa, Tommaso^1,2,3,5  Duca, Sergio^1,2,3  Rocca, Paola^4,5 

[1] Univ Turin, Koelliker Hosp, GCS fMRI, Turin, Italy

[2] Univ Turin, Dept Psychol, Via Giuseppe Verdi 10, I-10124 Turin, Italy

[3] Univ Turin, Dept Psychol, Funct Neuroimaging & Complex Neural Syst FOCUS La, Turin, Italy

[4] Univ Turin, Dept Neurosci Rita Levi Montalcini, Turin, Italy

[5] Univ Turin, Neurosci Inst Turin NIT, Turin, Italy

关键词: Schizophrenia;    Ultra-high risk;    Activation likelihood estimation;    Psychosis;    Voxel-based morphometry;    Signed differential mapping;    Behavioral analysis;    Coordinate-based meta-analysis;    Salience network;   

DOI  :  10.1016/j.neubiorev.2021.01.010

来源: Elsevier

【 摘 要 】

Characterizing neuroanatomical markers of different stages of schizophrenia (SZ) to assess pathophysiological models of how the disorder develops is an important target for the clinical practice. We performed a meta analysis of voxel-based morphometry studies of genetic and clinical high-risk subjects (g-/c-HR), recently diagnosed (RDSZ) and chronic SZ patients (ChSZ). We quantified gray matter (GM) changes associated with these four conditions and compared them with contrast and conjunctional data. We performed the behavioral analysis and networks decomposition of alterations to obtain their functional characterization. Results reveal a corticalsubcortical, left-to-right homotopic progression of GM loss. The right anterior cingulate is the only altered region found altered among c-HR, RDSZ and ChSZ. Contrast analyses show left-lateralized insular, amygdalar and parahippocampal GM reduction in RDSZ, which appears bilateral in ChSZ. Functional decomposition shows involvement of the salience network, with an enlargement of the sensorimotor network in RDSZ and the thalamus-basal nuclei network in ChSZ. These findings support the current neuroprogressive models of SZ and integrate this deterioration with the clinical evolution of the disease.

【 授权许可】

Free