Interacting brain systems modulate memory consolidation

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:36

Review

McIntyre, Christa K.¹  McGaugh, James L.²  Williams, Cedric L.³ 

[1] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75080 USA

[2] Univ Calif Irvine, Dept Neurobiol & Behav, Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA

[3] Univ Virginia, Neurosci & Behav Program, Dept Psychol, Charlottesville, VA 22904 USA

关键词: Stress;    Emotion;    Plasticity;    Modulation;    Synapse;    Amygdala;    Epinephrine;    Norepinephrine;    Vagus nerve;   

DOI  :  10.1016/j.neubiorev.2011.11.001

来源: Elsevier

【 摘 要 】

Emotional arousal influences the consolidation of long-term memory. This review discusses experimental approaches and relevant findings that provide the foundation for current understanding of coordinated interactions between arousal activated peripheral hormones and the brain processes that modulate memory formation. Rewarding or aversive experiences release the stress hormones epinephrine (adrenalin) and glucocorticoids from the adrenal glands into the bloodstream. The effect of these hormones on memory consolidation depends upon binding of norepinephrine to beta-adrenergic receptors in the basolateral complex of the amygdala (BLA). Much evidence indicates that the stress hormones influence release of norepinephrine in the BLA through peripheral actions on the vagus nerve which stimulates, through polysynaptic connections, cells of the locus coenileus to release norepinephrine. The BLA influences memory storage by actions on synapses, distributed throughout the brain, that are engaged in sensory and cognitive processing at the time of amygdala activation. The implications of the activation of these stress-activated memory processes are discussed in relation to stress-related memory disorders. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free