期刊论文详细信息
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 卷:115
Pre-clinical models of reward deficiency syndrome: A behavioral octopus
Review
Gondre-Lewis, Marjorie C.1,2  Bassey, Rosemary2,3  Blum, Kenneth4 
[1] Howard Univ, Coll Med, Dept Anat, 520 W St NW, Washington, DC 20059 USA
[2] Howard Univ, Coll Med, Dev Neuropsychopharmacol Lab, 520 W St NW, Washington, DC 20059 USA
[3] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Sci Educ, 500 Hofstra Univ, Hempstead, NY 11549 USA
[4] Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA USA
关键词: Animal models of reward deficiency;    Dopamine;    Reward;    Alcohol-preferring P rat;    Maternal deprivation;    Early life stress;    Helpless mouse (HL);    Wistar Kyoto (WKY) rat;    Addiction;    Gambling disorder;    Alcohol use disorder;    PTSD;    Compulsive eating disorder;    Roman;    APOSUS;    Knockout rats;    mGluR2;   
DOI  :  10.1016/j.neubiorev.2020.04.021
来源: Elsevier
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【 摘 要 】

Individuals with mood disorders or with addiction, impulsivity and some personality disorders can share in common a dysfunction in how the brain perceives reward, where processing of natural endorphins or the response to exogenous dopamine stimulants is impaired. Reward Deficiency Syndrome (RDS) is a polygenic trait with implications that suggest cross-talk between different neurological systems that include the known reward pathway, neuroendocrine systems, and motivational systems. In this review we evaluate well-characterized animal models for their construct validity and as potential models for RDS. Animal models used to study substance use disorder, major depressive disorder (MDD), early life stress, immune dysregulation, attention deficit hyperactivity disorder (ADHD), post traumatic stress disorder (PTSD), compulsive gambling and compulsive eating disorders are discussed. These disorders recruit underlying reward deficiency mechanisms in multiple brain centers. Because of the widespread and remarkable array of associated/overlapping behavioral manifestations with a common root of hypodopaminergia, the basic endophenotype recognized as RDS is indeed likened to a behavioral octopus. We conclude this review with a look ahead on how these models can be used to investigate potential therapeutics that target the underlying common deficiency.

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