Opposite regulation of conditioned place preference and intravenous drug self-administration in rodent models: Motivational and non-motivational examples

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:116

Review

Green, Thomas A.¹  Bardo, Michael T.² 

[1] Univ Texas Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA

[2] Univ Kentucky, Dept Psychol, BBSRB Room 447, Lexington, KY 40536 USA

关键词: Reward;    Animal models;    Conditioned place preference;    Incentive salience;    Addiction;    Incentive sensitization;    Motivation;    Dose-response functions;    Dose-response curves dose effect;    Discrepancies;    Drug abuse;    Self-administration;    Reinforcement;   

DOI  :  10.1016/j.neubiorev.2020.06.006

来源: Elsevier

【 摘 要 】

Although developed from a common antecedent, conditioned place preference (CPP) and intravenous drug self-administration (SA) represent different behavioral paradigms, each with strong face validity. The field has treated results from these studies largely interchangeably; however, there is considerable evidence of opposite modulation of CPP vs. SA. This review outlines four manipulations that differentially affect CPP and SA based on alterations of motivation. These examples are contrasted with one example of differential CPP and SA results that can be explained by simple parallel shifts in dose-response functions. The final two examples have yet to be classified as motivation-based or parallel shifts. Important aspects, including motivation, volitional control of drug administration, reward, and the role of cues are discussed. One major conclusion of this paper is that explanations for apparent discrepancies between CPP and SA require full dose effect functions and assessment of PR breakpoints. Overall, this manuscript offers a more nuanced insight into how CPP and SA can be used to study different aspects of substance use disorders.

【 授权许可】

Free