The cyclic AMP phenotype of fragile X and autism

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:32

Review

Kelley, Daniel J.^1,2,3  Bhattacharyya, Anita⁴  Lahvis, Garet P.⁵  Yin, Jerry C. P.⁶  Malter, Jim⁷  Davidson, Richard J.¹ 

[1] Univ Wisconsin, Waisman Ctr, Waisman Lab Brain Imaging & Behav, Madison, WI 53705 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Neurosci Training Program, Madison, WI 53705 USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Med Sci Training Program, Madison, WI 53705 USA

[4] Univ Wisconsin, Waisman Ctr, Stem Cells & Dev Disorders Lab, Madison, WI 53705 USA

[5] Univ Wisconsin, Dept Surg, Madison, WI 53705 USA

[6] Univ Wisconsin, Dept Genet, Madison, WI 53705 USA

[7] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53705 USA

关键词: Autism;    Fragile X;    Cyclic AMP;    cAMP;    Signal transduction;    FMRP;    FMR1;   

DOI  :  10.1016/j.neubiorev.2008.06.005

来源: Elsevier

【 摘 要 】

Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism. (c) 2008 Elsevier Ltd. All rights reserved

【 授权许可】

Free