Rodent medial and lateral orbitofrontal cortices represent unique components of cognitive maps of task space

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:108

Review

Bradfield, Laura A.^1,2  Hart, Genevra³ 

[1] Univ Technol Sydney, Ctr Neurosci & Regenerat Med, Sydney, NSW 2007, Australia

[2] St Vincents Hosp Sydney Ltd, St Vincents Ctr Appl Med Res, Sydney, NSW 2010, Australia

[3] Univ New South Wales, Decis Neurosci Lab, Sch Psychol, Sydney, NSW 2052, Australia

关键词: Medial orbitofrontal cortex;    Lateral orbitofrontal cortex;    Decision-making;    Cognitive map of task space;    Goal-directed action;    Model-based reinforcement learning;   

DOI  :  10.1016/j.neubiorev.2019.11.009

来源: Elsevier

【 摘 要 】

The orbitofrontal cortex (OFC) has been proposed to function as a cognitive map of task space: a mental model of the steps involved in a task. This idea has proven popular because it provides a cohesive explanation for a number of disparate findings regarding the OFC's role in a broad array of tasks. Concurrently, evidence has begun to reveal the functional heterogeneity of OFC subregions, particularly the medial and lateral OFC. How these subregions uniquely contribute to the OFC's role as a cognitive map of task space, however, has not been explored. Here we propose that, in rodents, the lateral OFC represents the agent's initial position within that task map (i.e. initial state), determining which actions are available as a consequence of that position, whereas the medial OFC represents the agent's future position within the task map (i.e. terminal state), influencing which actions are selected to achieve that position. We argue that these processes are achieved somewhat independently and somewhat interdependently, and are achieved through similar but non-identical circuitry.

【 授权许可】

Free