Dietary phospholipids: Role in cognitive processes across the lifespan

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:111

Review

Schverer, Marina^1,2  O'Mahony, Siobhain M.^1,2  O'Riordan, Kenneth J.¹  Donoso, Francisco^1,3  Roy, Bernard L.⁴  Stanton, Catherine^1,5  Dinan, Timothy G.^1,3  Schellekens, Harriet^1,2  Cryan, John F.^1,2 

[1] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland

[2] Univ Coll Cork, Dept Anat & Neurosci, Rin 3-85,Western Gateway Bldg, Cork, Ireland

[3] Univ Coll Cork, Dept Psychiat & Neurobehav Sci, Cork, Ireland

[4] Cremo SA, Fribourg, Switzerland

[5] Teagasc, Food Res Ctr, Moorepk, Cork, Ireland

关键词: Dietary phospholipids;    Cognition;    Brain health;    Stress;    Ageing;    Gut microbiota;   

DOI  :  10.1016/j.neubiorev.2020.01.012

来源: Elsevier

【 摘 要 】

Chronic stress and ageing are two of the most important factors that negatively affect cognitive processes such as learning and memory across the lifespan. To date, pharmacological agents have been insufficient in reducing the impact of both on brain health, and thus, novel therapeutic strategies are required. Recent research has focused on nutritional interventions to modify behaviour and reduce the deleterious consequences of both stress and ageing. In this context, emerging evidence indicate that phospholipids, a specific type of fat, are capable of improving a variety of cognitive processes in both animals and humans. The mechanisms underlying these positive effects are actively being investigated but as of yet are not fully elucidated. In this review, we summarise the preclinical and clinical studies available on phospholipid-based strategies for improved brain health across the lifespan. Moreover, we summarize the hypothesized direct and indirect mechanisms of action of these lipid-based interventions which may be used to promote resilience to stress and improve age-related cognitive decline in vulnerable populations.

【 授权许可】

Free