Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:117

Review

Van den Bergh, Bea R. H.^1,2  van den Heuvel, Marion I.³  Lahti, Marius⁴  Braeken, Marijke⁵  de Rooij, Susanne R.⁶  Entringer, Sonja^7,8  Hoyer, Dirk⁹  Roseboom, Tessa^6,10  Raikkonen, Katri⁴  King, Suzanne^11,12  Schwab, Matthias¹³ 

[1] Katholieke Univ Leuven, Res Grp Hlth Psychol, Fac Psychol & Educ Sci, Leuven, Belgium

[2] Flemish Govt, Dept Welf Publ Hlth & Family, Brussels, Belgium

[3] Wayne State Univ, Merrill Palmer Skillman Inst Child & Family Dev, Detroit, MI USA

[4] Univ Helsinki, Dept Psychol & Logoped, Fac Med, Helsinki, Finland

[5] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Rehabil Res Ctr, Hasselt, Belgium

[6] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands

[7] Charite Univ Med Berlin, Inst Med Psychol, Berlin, Germany

[8] Univ Calif Irvine, Dev Hlth & Dis Res Program, Irvine, CA USA

[9] Jena Univ Hosp, Hans Berger Dept Neurol, Biomagnet Ctr, Jena, Germany

[10] Univ Amsterdam, Acad Med Ctr, Dept Obstet & Gynaecol, Amsterdam, Netherlands

[11] McGill Univ, Douglas Hosp Res Ctr, Montreal, PQ, Canada

[12] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[13] Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

关键词: Fetal programming;    Maternal psychological distress;    Life events;    Disaster exposure;    Objective stress;    Anxiety;    Pregnancy-specific anxiety;    Depression;    Autism;    Attention deficit hyperactivity disorder (ADHD);    Schizophrenia;    Psychiatric disorders;    Telomere biology;    Epigenetics;    Gut microbiome;    Cortisol;    HPA-axis;    Heart rate variability;    Autonomic nervous system;    Event related potential (ERP);    Functional magnetic resonance imaging (fMRI);    Brain network connectivity;    EEG;   

DOI  :  10.1016/j.neubiorev.2017.07.003

来源: Elsevier

【 摘 要 】

Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system.

【 授权许可】

Free