Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:58

Article; Proceedings Paper

Da Cunha, Claudio¹  Boschen, Suelen L.¹  Gomez-Aa, Alexander¹  Ross, Erika K.²  Gibson, William S. J.²  Min, Hoon-Ki^2,3  Lee, Kendall H.^2,3  Blaha, Charles D.⁴ 

[1] Univ Fed Parana, Dept Fattnacol, BR-80060000 Curitiba, PR, Brazil

[2] Mayo Clin, Dept Neurol Surg, Rochester, MN USA

[3] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN USA

[4] Univ Memphis, Dept Psychol, Memphis, TN 38152 USA

关键词: Deep brain stimulation;    Striatum;    Subthalamic nucleus;    Globus pallidus;    Substantia nigra;    Electrochemistry;    Voltammetry;    Functional magnetic resonance imaging;    Pig;    Human;   

DOI  :  10.1016/j.neubiorev.2015.02.003

来源: Elsevier

【 摘 要 】

This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BC functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free