Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:80

Editorial Material

Thomsen, Kristine Romer¹  Callesen, Mette Buhl¹  Ewing, Sarah W. Feldstein² 

[1] Aarhus Univ, Dept Psychol & Behav Sci, Ctr Alcohol & Drug Res, Bartholins Alle 10, DK-8000 Aarhus C, Denmark

[2] Oregon Hlth & Sci Univ, Dept Child & Adolescent Psychiat, Mail Code DC7,3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

关键词: Cannabis;    Delta-9-tetrahydrocannabinol;    Cannabidiol;    Potency;    Cognition;    Memory;    Learning;   

DOI  :  10.1016/j.neubiorev.2017.05.025

来源: Elsevier

【 摘 要 】

Cannabis use represents a major public health issue throughout the globe. Yet, we still lack the most fundamental knowledge on long-term effects of cannabis on neural, cognitive, and behavioral function. Part of this stems from how cannabis has been measured historically. To this end, most empirical examinations of cannabis have consolidated all types of cannabis collectively. However, this approach obscures differences in how cannabinoids operate. In this commentary, we address the contrasting properties of tetrahydrocannabinol (THC) and cannabidiol (CBD) and their opposing effects on cognitive function. In addition, we address the increase in cannabis potency throughout the past two decades and how that impacts generalizability of early data to evaluations of contemporary public health. We underscore the urgent need for future research to disaggregate examination of THC from CBD, along with the importance of measuring cannabis potency to more effectively unravel its influence on cognitive function and other health issues.

【 授权许可】

Free