Consideration of species differences in developing novel molecules as cognition enhancers

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:37

Review

Young, Jared W.¹  Jentsch, J. David²  Bussey, Timothy J.³  Wallace, Tanya L.⁴  Hutcheson, Daniel M.⁵ 

[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[2] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[3] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[4] SRI Int, Ctr Neurosci, Menlo Pk, CA 94025 USA

[5] Maccine Pte Ltd, Singapore 117684, Singapore

关键词: Species;    Differences;    Mice;    Rats;    Non-human primates;    Monkeys;    Human primates;    CNTRICS;    Cognitive;    Attention;    Reversal learning;    Impulsivity;   

DOI  :  10.1016/j.neubiorev.2012.10.002

来源: Elsevier

【 摘 要 】

The NIH-funded CNTRICS initiative has coordinated efforts to promote the vertical translation of novel procognitive molecules from testing in mice, rats and non-human primates, to clinical efficacy in patients with schizophrenia. CNTRICS highlighted improving construct validation of tasks across species to increase the likelihood that the translation of a candidate molecule to humans will be successful. Other aspects of cross-species behaviors remain important however. This review describes cognitive tasks utilized across species, providing examples of differences and similarities of innate behavior between species, as well as convergent construct and predictive validity. Tests of attention, olfactory discrimination, reversal learning, and paired associate learning are discussed. Moreover, information on the practical implication of species differences in drug development research is also provided. The issues covered here will aid in task development and utilization across species as well as reinforcing the positive role preclinical research can have in developing procognitive treatments for psychiatric disorders. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free