The clinical and prognostic value of motor abnormalities in psychosis, and the importance of instrumental assessment

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:80

Review

van Harten, Peter N.^1,2  Walther, Sebastian³  Kent, Jerillyn S.⁴  Sponheim, Scott R.⁴  Mittal, Vijay A.⁵ 

[1] Maastricht Univ, Med Ctr, Dept Psychiat & Psychol, Maastricht, Netherlands

[2] Psychiat Ctr GGz Cent, Amersfoort, Netherlands

[3] Univ Bern, Univ Hosp Psychiat, Translat Res Ctr, Bern, Switzerland

[4] Minneapolis VA Hlth Care Syst, Minneapolis, MN USA

[5] Northwestern Univ, Dept Psychol, Dept Psychiat, Inst Policy Res,Dept Med Social Sci, Evanston, IL USA

关键词: Instrumental assessment;    Motor abnormalities;    Movement disorders;    Psychosis;    Ultra high risk for psychosis;    Epidemiology;    Prognosis;   

DOI  :  10.1016/j.neubiorev.2017.06.007

来源: Elsevier

【 摘 要 】

Motor abnormalities comprise several clinical signs intrinsic to psychosis. Critically, these features are of prognostic value in individuals at-risk for psychosis, and for those in early stages of psychotic disorders. Motor abnormalities such as tremor, rigidity, and neurological soft signs often go unrecognized. Currently, advances in this area are limited by a paucity of theoretical conceptions categorizing or linking these behaviours to underlying neurobiology affected in psychosis. However, emerging technological advances have significantly improved the ability to detect and assess motor abnormalities with objective instruments in a timely and reliable manner. Further, converging evidence has laid the groundwork for theoretically and empirically derived categorization and conceptualization. This review summarizes these advances, stressing the importance of motor abnormalities for understanding vulnerability across different stages of psychosis and introducing these innovative instrumental approaches. Patients, researchers and clinicians will benefit from these new developments, as better assessment aids the development of targeted interventions to ultimately improve the care for individuals experiencing psychosis.

【 授权许可】

Free