Context and trade-offs characterize real-world threat detection systems: A review and comprehensive framework to improve research practice and resolve the translational crisis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:115

Review

Fendt, Markus^1,2  Parsons, Michael H.³  Apfelbach, Raimund⁴  Carthey, Alexandra J. R.⁵  Dickman, Chris R.⁶  Endres, Thomas⁷  Frank, Anke S. K.^6,8,9  Heinz, Daniel E.^10,11  Jones, Menna E.⁸  Kiyokawa, Yasushi¹²  Kreutzmann, Judith C.¹  Roelofs, Karin^13,14  Schneider, Miriam¹⁵  Sulger, Julia^11,16  Wotjak, Carsten T.^11,18  Blumstein, Daniel T.¹⁷ 

[1] Otto von Guericke Univ, Inst Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdeburg, Germany

[2] Otto von Guericke Univ, Ctr Behav Brain Sci CBBS, Magdeburg, Germany

[3] Fordham Univ, Dept Biol Sci, Bronx, NY 10458 USA

[4] Univ Tubingen, Zool Inst, Neurobiol, Tubingen, Germany

[5] Macquarie Univ, Dept Biol Sci, N Ryde, NSW, Australia

[6] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia

[7] Otto von Guericke Univ, Inst Physiol, Magdeburg, Germany

[8] Univ Tasmania, Sch Nat Sci, Hobart, Tas, Australia

[9] Univ Cologne, Inst Bot, Cologne, Germany

[10] Max Planck Sch Cognit, Leipzig, Germany

[11] Max Planck Inst Psychiat, RG Neuronal Plast, Munich, Germany

[12] Univ Tokyo, Lab Vet Ethol, Tokyo, Japan

[13] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands

[14] Radboud Univ Nijmegen, Behav Sci Inst, Nijmegen, Netherlands

[15] Sokoine Univ Agr, APOPO, Morogoro, Tanzania

[16] Int Max Planck Res Sch Translat Psychiat IMPRS TP, Munich, Germany

[17] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA

[18] Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany

关键词: Animal models;    Bench-to-bedside gap;    Fear;    Anxiety;    Predator-prey models;    Translational neuroscience;   

DOI  :  10.1016/j.neubiorev.2020.05.002

来源: Elsevier

【 摘 要 】

A better understanding of context in decision-making-that is, the internal and external conditions that modulate decisions-is required to help bridge the gap between natural behaviors that evolved by natural selection and more arbitrary laboratory models of anxiety and fear. Because anxiety and fear are mechanisms evolved to manage threats from predators and other exigencies, the large behavioral, ecological and evolutionary literature on predation risk is useful for re-framing experimental research on human anxiety-related disorders. We review the trade-offs that are commonly made during antipredator decision-making in wild animals along with the context under which the behavior is performed and measured, and highlight their relevance for focused laboratory models of fear and anxiety. We then develop an integrative mechanistic model of decision-making under risk which, when applied to laboratory and field settings, should improve studies of the biological basis of normal and pathological anxiety and may therefore improve translational outcomes.

【 授权许可】

Free