Disentangling the influences of multiple thalamic nuclei on prefrontal cortex and cognitive control

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:128

Article

Phillips, Jessica M.¹  Kambi, Niranjan A.¹  Redinbaugh, Michelle J.¹  Mohanta, Sounak¹  Saalmann, Yuri B.^1,2 

[1] Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA

[2] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, 1202 Capitol Ct, Madison, WI 53715 USA

关键词: Cognitive control;    Prefrontal cortex;    Thalamus;    Mediodorsal nucleus;    Ventroanterior nucleus;    Intralaminar nuclei;    Anteromedial nucleus;    Pulvinar;    Thalamocortical;    Corticothalamic;    Basal ganglia;   

DOI  :  10.1016/j.neubiorev.2021.06.042

来源: Elsevier

【 摘 要 】

The prefrontal cortex (PFC) has a complex relationship with the thalamus, involving many nuclei which occupy predominantly medial zones along its anterior-to-posterior extent. Thalamocortical neurons in most of these nuclei are modulated by the affective and cognitive signals which funnel through the basal ganglia. We review how PFC-connected thalamic nuclei likely contribute to all aspects of cognitive control: from the processing of information on internal states and goals, facilitating its interactions with mnemonic information and learned values of stimuli and actions, to their influence on high-level cognitive processes, attentional allocation and goaldirected behavior. This includes contributions to transformations such as rule-to-choice (parvocellular mediodorsal nucleus), value-to-choice (magnocellular mediodorsal nucleus), mnemonic-to-choice (anteromedial nucleus) and sensory-to-choice (medial pulvinar). Common mechanisms appear to be thalamic modulation of cortical gain and cortico-cortical functional connectivity. The anatomy also implies a unique role for medial PFC in modulating processing in thalamocortical circuits involving other orbital and lateral PFC regions. We further discuss how cortico-basal ganglia circuits may provide a mechanism through which PFC controls cortico-cortical functional connectivity.

【 授权许可】

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