Lithium therapy and weight change in people with bipolar disorder: A systematic review and meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:134

Review

Gomes-da-Costa, Susana¹  Marx, Wolfgang²  Corponi, Filippo³  Anmella, Gerard¹  Murru, Andrea¹  Teresa Pons-Cabrera, Maria¹  Gimenez-Palomo, Anna¹  Gutierrez-Arango, Felipe¹  Daniel Llach, Cristian¹  Fico, Giovanna¹  Kotzalidis, Georgios D.⁴  Verdolini, Norma¹  Valenti, Marc¹  Berk, Michael²  Vieta, Eduard¹  Pacchiarotti, Isabella¹ 

[1] Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, 170 Villarroel St,12-0, Barcelona 08036, Spain

[2] Deakin Univ, Sch Med, IMPACT Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, Geelong, Vic, Australia

[3] Univ Edinburgh, Sch Informat, Edinburgh, Midlothian, Scotland

[4] Sapienza Univ Rome, St Andrea Univ Hosp, Sch Med & Psychol, Dept Neurosci Mental Hlth & Sensory Organs NESMOS, Via Grottarossa 1035-1039, I-00189 Rome, Italy

关键词: Lithium;    Bipolar disorder;    Weight gain;    Mood stabilizers;    Depression;    Mania;    Mood disorders;    Psychiatry;    Neurosciences;   

DOI  :  10.1016/j.neubiorev.2021.07.011

来源: Elsevier

【 摘 要 】

Lithium remains the gold standard maintenance treatment for Bipolar Disorder (BD). However, weight gain is a side effect of increasing relevance due to its metabolic implications. We conducted a systematic review and meta-analysis aimed at summarizing evidence on the use of lithium and weight change in BD. We followed the PRISMA methodology, searching Pubmed, Scopus and Web of Science. From 1003 screened references, 20 studies were included in the systematic review and 9 included in the meta-analysis. In line with the studies included in the systematic review, the meta-analysis revealed that weight gain with lithium was not significant, noting a weight increase of 0.462 Kg (p = 0158). A shorter duration of treatment was significantly associated with more weight gain. Compared to placebo, there were no significant differences in weight gain. Weight gain was significantly lower with lithium than with active comparators. This work reveals a low impact of lithium on weight change, especially compared to some of the most widely used active comparators. Our results could impact clinical decisions.

【 授权许可】

Free