Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:75

Review

Richard, Annie E.¹  Scheffer, Ingrid E.^2,3,4  Wilson, Sarah J.^1,2 

[1] Univ Melbourne, Melbourne Sch Psychol Sci, 12th Floor Redmond Barry Bldg, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Florey Inst Austin Hlth, Dept Med, Heidelberg, Vic 3084, Australia

[3] Univ Melbourne, Dept Paediat, Melbourne, Vic 3084, Australia

[4] Royal Childrens Hosp, Dept Neurol, Melbourne, Vic 3084, Australia

关键词: Epilepsy;    Autism spectrum disorder;    Broader autism phenotype;    Facial emotion recognition;    Theory of mind;    Meta-analysis;   

DOI  :  10.1016/j.neubiorev.2016.12.036

来源: Elsevier

【 摘 要 】

Richard, A.E., I.E. Scheffer and S.J. Wilson. Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2016. To inform on mechanisms underlying the comorbidity of epilepsy and autism spectrum disorder (ASD), we conducted meta-analyses to test whether impaired facial emotion recognition (FER) and theory of mind (ToM), key phenotypic traits of ASD, are more common in people with epilepsy (PWE) than controls. We contrasted these findings with those of relatives of individuals with ASD (ASD-relatives) compared to controls. Furthermore, we examined the relationship of demographic (age, IQ, sex) and epilepsy-related factors (epilepsy onset age, duration, seizure laterality and origin) to FER and ToM. Thirty-one eligible studies of PWE (including 1449 individuals: 77% with temporal lobe epilepsy), and 22 of ASD-relatives (N=1295) were identified by a systematic database search. Analyses revealed reduced FER and ToM in PWE compared to controls (p < 0.001), but only reduced ToM in ASD-relatives (p < 0.001). ToM was poorer in PWE than ASD-relatives. Only weak associations were found between FER and ToM and epilepsy-related factors. These findings suggest shared mechanisms between epilepsy and ASD, independent of intellectual disability. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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