The neuropsychiatry of neuroacanthocytosis syndromes

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:35

Review

Walterfang, Mark^1,2  Evans, Andrew^1,3  Looi, Jeffrey Chee Leong⁴  Jung, Hans H.⁷  Danek, Adrian⁸  Walker, Ruth H.^5,6  Velakoulis, Dennis^1,2 

[1] Royal Melbourne Hosp, Neuropsychiat Unit, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia

[3] Royal Melbourne Hosp, Dept Neurosci, Melbourne, Vic 3050, Australia

[4] Australian Natl Univ, Sch Med, Res Ctr Neurosci Ageing, Canberra, ACT, Australia

[5] James J Peters Vet Affairs Med Ctr, Dept Neurol, New York, NY USA

[6] Mt Sinai Sch Med, New York, NY USA

[7] Univ Zurich Hosp, Dept Neurol, Zurich, Switzerland

[8] Univ Munich, Dept Neurol, D-8000 Munich, Germany

关键词: Neuroacanthocytosis;    Chorea-acanthocytosis;    McLeod syndrome;    Striatum;    Obsessive-compulsive disorder;    Schizophrenia;    Executive impairment;   

DOI  :  10.1016/j.neubiorev.2011.01.001

来源: Elsevier

【 摘 要 】

The neuroacanthocytoses are a group of disorders characterised by peripheral blood acanthocytes, central nervous system as well as neuromuscular symptoms. These disorders uniformly result in pathology in the basal ganglia, which account for the characteristic motor symptoms such as chorea or dystonia, but may also account for the apparent elevated rates of major mental disorders in these syndromes. Elevated rates of dysexecutive syndromes, obsessive-compulsive disorder, depression and schizophrenia-like psychosis appear to occur in chorea-acanthocytosis, McLeod's syndrome, pantothenate kinase-associated neurodegeneration, and Huntington's disease-like 2. Disruptions to key frontostriatal loops secondary to pathology in the striatum and pallidum appear to predispose individuals to major neuropsychiatric syndromes: however, treatment can be instituted for a number of these manifestations, which lessens the overall burden of disease in neuroacanthocytosis patients and their families. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free