Identifying the role of pre-and postsynaptic GABAB receptors in behavior

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:57

Review

Kasten, Chelsea R.¹  Boehm, Stephen L., II² 

[1] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46202 USA

[2] Indiana Alcohol Res Ctr, Indianapolis, IN USA

关键词: GABA(B) receptor;    Isoform;    Knockout;    Cognition;    Depression;    Drugs of abuse;   

DOI  :  10.1016/j.neubiorev.2015.08.007

来源: Elsevier

【 摘 要 】

Although many reviews exist characterizing the molecular differences of GABA(B) receptor isoforms, there is no current review of the in vivo effects of these isoforms. The current review focuses on whether the GABA(B1a) and GABA(B1b) isoforms contribute differentially to behaviors in isoform knockout mice. The roles of these receptors have primarily been characterized in cognitive, anxiety, and depressive phenotypes. Currently, the field supports a role of GABA(B1a) in memory maintenance and protection against an anhedonic phenotype, whereas GABA(B1b) appears to be involved in memory formation and a susceptibility to developing an anhedonic phenotype. Although GABA(B) receptors have been strongly implicated in drug abuse phenotypes, no isoform-specific work has been done in this field. Future directions include developing site-specific isoform knockdown to identify the role of different brain regions in behavior, as well as identifying how these isoforms are involved in development of behavioral phenotypes. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free