Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:74

Review

Murphy, M. O.¹  Cohn, D. M.¹  Loria, A. S.¹ 

[1] Univ Kentucky, Dept Pharmacol & Nutr Sci, 900 S Limestone St,562 CT Wethington Bldg, Lexington, KY 40536 USA

关键词: Early life stress;    Adverse childhood experiences;    Cardiovascular risk;    Hypertension;    Maternal separation;   

DOI  :  10.1016/j.neubiorev.2016.07.018

来源: Elsevier

【 摘 要 】

The Developmental Origins of Health and Disease (DOHaD) hypothesizes that environmental insults during childhood programs the individual to develop chronic disease in adulthood. Emerging epidemiological data strongly supports that early life stress (ELS) given by the exposure to adverse childhood experiences is regarded as an independent risk factor capable of predicting future risk of cardiovascular disease. Experimental animal models utilizing chronic behavioral stress during postnatal life, specifically maternal separation (MatSep) provides a suitable tool to elucidate molecular mechanisms by which ELS increases the risk to develop cardiovascular disease, including hypertension. The purpose of this review is to highlight current epidemiological studies linking ELS to the development of cardiovascular disease and to discuss the potential molecular mechanisms identified from animal studies. Overall, this review reveals the need for future investigations to further clarify the molecular mechanisms of ELS in order to develop more personalized therapeutics to mitigate the long-term consequences of chronic behavioral stress including cardiovascular and heart disease in adulthood. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free