Dynamic coupling between the central and autonomic nervous systems during sleep: A review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:90

Review

de Zambotti, Massimiliano¹  Trinder, John²  Silvani, Alessandro³  Colrain, Ian M.^1,2  Baker, Fiona C.^1,4 

[1] SRI Int, Ctr Hlth Sci, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA

[2] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia

[3] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy

[4] Univ Witwatersrand, Sch Physiol, Brain Funct Res Grp, Johannesburg, South Africa

关键词: Cortico-cardiac interplay;    Sleep;    Autonomic nervous system;    Central nervous system;    Heart rate variability;    Baroreflex;    Sympathetic;    Vagal;    Electroencephalography;    Electrocardiography;   

DOI  :  10.1016/j.neubiorev.2018.03.027

来源: Elsevier

【 摘 要 】

Sleep is characterized by coordinated cortical and cardiac oscillations reflecting communication between the central (CNS) and autonomic (ANS) nervous systems. Here, we review fluctuations in ANS activity in association with CNS-defined sleep stages and cycles, and with phasic cortical events during sleep (e.g., arousals, K-complexes). Recent novel analytic methods reveal a dynamic organization of integrated physiological networks during sleep and indicate how multiple factors (e.g., sleep structure, age, sleep disorders) affect CNS-ANS coupling. However, these data are mostly correlational and there is a lack of clarity of the underlying physiology, making it challenging to interpret causality and direction of coupling. Experimental manipulations (e.g., evoking K-complexes or arousals) provide information on the precise temporal sequence of cortical-cardiac activity, and are useful for investigating physiological pathways underlying CNS-ANS coupling. With the emergence of new analytical approaches and a renewed interest in ANS and CNS communication during sleep, future work may reveal novel insights into sleep and cardiovascular interactions during health and disease, in which coupling could be adversely impacted.

【 授权许可】

Free