The role of maternal immune activation in altering the neurodevelopmental trajectories of offspring: A translational review of neuroimaging studies with implications for autism spectrum disorder and schizophrenia

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:104

Review

Guma, Elisa^1,2  Plitrnan, Eric^2,3  Chakravarty, M. Mallar^1,2,3,4 

[1] McGill Univ, Integrated Program Neurosci, 845 Sherbrooke St W, Montreal, PQ H3A 0G4, Canada

[2] Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Computat Brain Anat CoBrA Lab, Verdun, PQ H4H 1R3, Canada

[3] McGill Univ, Dept Psychiat, 845 Sherbrooke St W, Montreal, PQ H3A 0G4, Canada

[4] McGill Univ, Dept Biol & Biomed Engn, 845 Sherbrooke St W, Montreal, PQ H3A 0G4, Canada

关键词: Neurodevelopment;    Maternal Immune Activation;    Maternal Inflammation;    Neuroimaging;    Schizophrenia;    Autism;    Translational;   

DOI  :  10.1016/j.neubiorev.2019.06.020

来源: Elsevier

【 摘 要 】

Exposure to maternal infection in utero increases the risk that offspring will develop neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Research in animal models has confirmed this link and demonstrated that maternal immune activation (MIA) is sufficient to induce alterations in offspring neurodevelopment. Building homology between observations made in humans and animal models is a challenge; however, neuroimaging allows for homologous characterization of developmental trajectories across species. This systematic review aims to discuss findings from human and animal studies that performed neuroimaging in offspring exposed to maternal infection, inflammation, or MIA, in the context of neurodevelopmental disorders.

【 授权许可】

Free