From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:90

Review

Stapelberg, N. J. C.^1,2  Pratt, R.³  Neumann, D. L.⁴  Shum, D. H. K.^4,5  Brandis, S.⁶  Muthukkumarasamy, V.⁷  Stantic, B.⁷  Blumenstein, M.⁸  Headrick, J. P.⁹ 

[1] Bond Univ, Fac Hlth Sci & Med, 14 Univ Dr, Robina, Qld 4226, Australia

[2] Gold Coast Hosp & Hlth Serv, 14 Univ Dr, Robina, Qld 4226, Australia

[3] Gold Coast Univ Hosp, Gold Coast, Qld, Australia

[4] Griffith Univ, Sch Appl Psychol, Gold Coast, Qld, Australia

[5] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China

[6] Bond Univ, Fac Hlth Sci & Med, Southport, Qld 4229, Australia

[7] Griffith Univ, Sch Informat & Commun Technol, Gold Coast, Qld 4222, Australia

[8] Univ Technol Sydney, Fac Engn & Informat Technol, Sydney, NSW, Australia

[9] Griffith Univ, Sch Med Sci, Gold Coast, Qld 4222, Australia

关键词: Major depressive disorder;    Critical transition;    Feedback loop transition biomarker;    Psycho-immune-neuroendocrine network;    Feedback loop;    Network motif;   

DOI  :  10.1016/j.neubiorev.2018.03.005

来源: Elsevier

【 摘 要 】

Background: Biological pathways underlying major depressive disorder (MDD) can be viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network comprises central nervous, immune, endocrine and autonomic systems, integrating biological mechanisms of MDD. Such networks exhibit recurrent motifs with specific functions, including positive and negative feedback loops, and are subject to critical transitions, influenced by feedback loop transitions (FLTs). Aims: We aim to identify critical feedback loops and their FLTs, as well sentinel network nodes (SNNs), key network nodes that drive FLTs, within the PINE network. Examples of biomarkers are provided which may reflect early warning signs of impending critical transition to MDD. Results: Disruption of homeostatic feedback loops reflects the physiological transition to MDD. Putative FLTs are identified within hypothalamic-pituitary-adrenal (HPA) and sympathetic-parasympathetic axes, the kynurenine pathway, gut function and dysbiosis. Conclusions: Progression from health to disease is driven by FLTs in the PINE network, which is likely to undergo changes characteristic of system instability. Biomarkers of system instability may effectively predict the critical transition to MDD.

【 授权许可】

Free