Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:108

Review

Horta, Marilyn¹  Kaylor, Kathryn¹  Feifel, David²  Ebner, Natalie C.^1,3 

[1] Univ Florida, Dept Psychol, POB 112250, Gainesville, FL 32611 USA

[2] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[3] Univ Florida, Inst Aging, Dept Aging & Geriatr Res, Gainesville, FL 32611 USA

关键词: Oxytocin;    Chronic administration;    Intranasal;    Pharmacological research;    Peptide;    Neuropeptide;    Hormone;   

DOI  :  10.1016/j.neubiorev.2019.10.012

来源: Elsevier

【 摘 要 】

Oxytocin (OT) subserves various physiological, behavioral, and cognitive processes. This paired with the ability to administer OT with minimal and inconsistent side effects has spurred research to explore its therapeutic potential. Findings from single-dose studies indicate that OT administration may be beneficial, at least under certain circumstances. The state of the field, however, is less clear regarding effects from chronic OT administration, which more closely resembles long-term treatment. To address this gap, this review synthesizes existing findings on the use of chronic OT administration in animal and human work. In addition to detailing the effects of chronic OT administration across different functional domains, this review highlights factors that have contributed to mixed findings. Based on this review, a basic framework of interrelated regulatory functions sensitive to chronic OT administration is offered. The paper also identifies future research directions across different contexts, populations, and outcomes, specifically calling for more systematic and standardized research on chronic OT administration in humans to supplement and expand what is currently known from preclinical work.

【 授权许可】

Free