Non-pharmacological factors that determine drug use and addiction

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:110

Article; Proceedings Paper

Ahmed, Serge H.^1,2  Badiani, Aldo^3,4  Miczek, Klaus A.^5,6  Mueller, Christian P.⁷ 

[1] Univ Bordeaux, Inst Malad Neurodegenerat, UMR 5293, 146 Rue Leo Saignat, F-33000 Bordeaux, France

[2] CNRS, Inst Malad Neurodegenerat, UMR 5293, 146 Rue Leo Saignat, F-33000 Bordeaux, France

[3] Sapienza Univ Rome, Dept Physiol & Pharmacol, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[4] Univ Sussex, Sch Psychol, SARIC, Brighton BN1 9RH, E Sussex, England

[5] Tufts Univ, Dept Psychol, Bacon Hall,530 Boston Ave, Medford, MA 02155 USA

[6] Sackler Sch Grad Biomed Sci, Dept Neurosci, Boston, MA 02111 USA

[7] Friedrich Alexander Univ Erlangen Nuremberg, Dept Psychiat & Psychotherapy, Schwabachanlage 6, D-91054 Erlangen, Germany

关键词: Drug abuse;    Drug addiction;    Drug instrumentalization;    Social stress;    Environment;   

DOI  :  10.1016/j.neubiorev.2018.08.015

来源: Elsevier

【 摘 要 】

Based on their pharmacological properties, psychoactive drugs are supposed to take control of the natural reward system to finally drive compulsory drug seeking and consumption. However, psychoactive drugs are not used in an arbitrary way as pure pharmacological reinforcement would suggest, but rather in a highly specific manner depending on non-pharmacological factors. While pharmacological effects of psychoactive drugs are well studied, neurobiological mechanisms of non-pharmacological factors are less well understood. Here we review the emerging neurobiological mechanisms beyond pharmacological reinforcement which determine drug effects and use frequency. Important progress was made on the understanding of how the character of an environment and social stress determine drug self-administration. This is expanded by new evidence on how behavioral alternatives and opportunities for drug instrumentalization generate different patterns of drug choice. Emerging evidence suggests that the neurobiology of non-pharmacological factors strongly determines pharmacological and behavioral drug action and may, thus, give rise for an expanded system's approach of psychoactive drug use and addiction.

【 授权许可】

Free