An emotional-response model of bipolar disorders integrating recent findings on amygdala circuits

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:118

Review

Bigot, Mathilde^1,2  Alonso, Mariana¹  Houenou, Josselin^3,4  Sarrazin, Samuel^3,4  Dargel, Aroldo A.¹  Lledo, Pierre-Marie¹  Henry, Chantal^1,5,6 

[1] Inst Pasteur, Percept & Memory Unit, CNRS, UMR3571, Paris, France

[2] Sorbonne Univ, Coll Doctoral, Paris, France

[3] Univ Paris Est, U955, INSERM, Creteil, France

[4] NeuroSpin Commissariat Energie Atom & Energies Al, Gif Sur Yvette, France

[5] Univ Paris, Paris, France

[6] Serv Hosp Univ, Dept Psychiat, GHU Paris Psychiat & Neurosci, Paris, France

关键词: Bipolar disorders;    Amygdala;    Dimensional approach;    Behavioral regulation;    Emotional processing;    Brain circuits;   

DOI  :  10.1016/j.neubiorev.2020.07.037

来源: Elsevier

【 摘 要 】

Because of our classification system limitations for defining psychiatric disorders and understanding their physiopathology, a new research area based on dimensions has emerged. It consists of exploring domains derived from fundamental behavioral components linked to neurobiological systems. Emotional processing is among the most affected dimensions in bipolar disorders (BD), but is excluded from the definition criteria. The purpose of this review is to synthesize the emotional responses disruption during the different phases of BD, using intensity and valence as the two key characteristics of emotions. We integrate those emotional disruptions into an original, emotion-based model contrasting with the current diagnostic frame built on mood. Emotional processing is underpinned by cortico-limbic circuits involving the amygdala. Recent publications showed the crucial role of the amygdala in emotional processes triggered by stimuli of negative, but also positive valence. We show how these neuroscience data can provide physiological basis for emotional disturbances observed in BD. We conclude with translational perspectives to improve the current knowledge about neural substrates underlying altered emotional responses characterizing BD.

【 授权许可】

Free