Tyrosine hydroxylase gene expression in varying forms of human pheochromocytoma

LIFE SCIENCES

卷:59

Article

Tumer, N ; Brown, JW ; Carballeira, A ; Fishman, LM

关键词: pheochromocytomas;    tyrosine hydroxylase;    gene expression;    catecholamines;    von Hippel-Lindau disease;    MEN 2B syndrome;   

DOI  :  10.1016/0024-3205(96)00497-3

来源: Elsevier

【 摘 要 】

We performed a comparative study of catecholamine content, tyrosine hydroxylase (TH) activity, and TH mRNA levels in normal human adrenals and various clinical forms of human pheochromocytoma. We studied sporadic, benign intra-adrenal chromaffin tumors and other non-malignant intra-adrenal tumors associated with multiple endocrine neoplasia type 2B (MEN 2B) and von Hippel-Lindau disease along with one extra-adrenal malignant pheochromocytoma. Our findings suggest substantial differences in TH transcriptional rates or the stability of TH mRNA or both may contribute to altered TH expression in human chromaffin cells associated with ''normal'' adrenal tissues and various forms of pheochromocytoma and distinctive patterns of expression in the different settings in which these tumors arise.

【 授权许可】

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