Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system

LIFE SCIENCES

卷:118

Review

Matsumoto, Takayuki¹  Lopes, Rheure A. M.²  Taguchi, Kumiko¹  Kobayashi, Tsuneo¹  Tostes, Rita C.² 

[1] Hoshi Univ, Inst Med Chem, Dept Physiol & Morphol, Shinagawa Ku, Tokyo 1428501, Japan

[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil

关键词: Diabetes;    Endothelial dysfunction;    ET-1;    Type 2 diabetes;    Vascular smooth muscle;   

DOI  :  10.1016/j.lfs.2013.12.216

来源: Elsevier

【 摘 要 】

The rising epidemic of diabetes worldwide is of significant concern. Although the ultimate objective is to prevent the development and find a cure for the disease, prevention and treatment of diabetic complications is very important. Vascular complications in diabetes, or diabetic vasculopathy, include macro- and microvascular dysfunction and represent the principal cause of morbidity and mortality in diabetic patients. Endothelial dysfunction plays a pivotal role in the development and progression of diabetic vasculopathy. Endothelin-1 (ET-1), an endothelial cell-derived peptide, is a potent vasoconstrictor with mitogenic, pro-oxidative and pro-inflammatory properties that are particularly relevant to the pathophysiology of diabetic vasculopathy. Overproduction of ET-1 is reported in patients and animal models of diabetes and the functional effects of ET-1 and its receptors are also greatly altered in diabetic conditions. The current therapeutic approaches in diabetes include glucose lowering, sensitization to insulin, reduction of fatty acids and vasculoprotective therapies. However, whether and how these therapeutic approaches affect the ET-1 system remain poorly understood. Accordingly, in the present review, we will focus on experimental and clinical evidence that indicates a role for ET-1 in diabetic vasculopathy and on the effects of current therapeutic approaches in diabetes on the vascular ET-1 system. (C) 2014 The Authors. Published by Elsevier Inc. This is an Open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

【 授权许可】

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