Neurotoxicant exposures and rates of Chronic Multisymptom Illness and Kansas Gulf War Illness criteria in Gulf War deployed women veterans

LIFE SCIENCES

卷:280

Article

Krengel, Maxine^1,3  Sullivan, Kimberly²  Heboyan, Vahe⁴  Zundel, Clara G.^1,3  Wilson, Col Candy⁵  Klimas, Nancy^6,7  Coughlin, Steven S.^8,9 

[1] Boston Univ, Sch Med, Boston, MA 02215 USA

[2] Boston Univ, Sch Publ Hlth, Boston, MA USA

[3] VA Boston Healthcare Syst, Boston, MA USA

[4] Augusta Univ, Med Coll Georgia, Populat Hlth Sci Dept, Hlth Econ & Modeling Div, Augusta, GA USA

[5] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD USA

[6] Miami VA Healthcare Syst, Miami, FL USA

[7] Nova Southeastern Univ, Dr Kiran C Patel Coll Osteopath Med, Inst Neuroimmune Med, Ft Lauderdale, FL 33314 USA

[8] Augusta Univ, Med Coll Georgia, Dept Populat Hlth Sci, Augusta, GA USA

[9] Charlie Norwood Vet Adm Med Ctr, Res Serv, Augusta, GA USA

关键词: Gulf War;    Gulf Wwar Iillness;    Neurotoxicant exposures;    Kansas case criteria;    Chronic Multisymptom Illness;    Persian Gulf War;   

DOI  :  10.1016/j.lfs.2021.119623

来源: Elsevier

【 摘 要 】

Aims: This study analyzed deployment-related exposures and risk of Persian Gulf War Illness (GWI) in women veterans from the Veterans Affairs (VA) Cooperative Studies Program 585 Gulf War Era Cohort and Biorepository (GWECB CSP#585). Main methods: We examined the associations between GW deployment-related exposures and case definitions for GWI in deployed GW women. Multivariate regression analyses controlling for demographic outcomes were performed. Key findings: Surveys were obtained from 202 GW deployed women veterans. Self-reported exposure to smoke from oil well fires as well as chemical and biological warfare were the only exposures significantly associated with the Center for Disease Control and Prevention (CDC) GWI criteria. Seventy-nine women were excluded from the rest of the analyses as they met Kansas GW illness exclusion criteria. Eligible women who self-reported deployment-related exposure to smoke from oil wells, pyridostigmine bromide (PB) pills, pesticide cream, pesticide treated uniforms, and insect baits were significantly more likely to meet the Kansas GWI criteria (n = 123) than those unexposed and exposures were related to Kansas symptom subdomain endorsements. Significance: These results suggest that women GW veterans reporting deployment related exposures of pesticide, oil well fire and PB pills are significantly more likely to meet the Kansas GWI criteria in this national cohort of GW women suggesting its utility in future studies. In addition, based on these results it appears that women exposed to particular toxicants during the war may benefit from more targeted treatment strategies dependent upon the mechanism of exposure of their toxicant induced outcomes.

【 授权许可】

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