Pluripotency of mesenchymal cells derived from synovial fluid in patients with temporomandibular joint disorder

LIFE SCIENCES

卷:89

Article

Koyama, Noriaki¹ 

[1] Kyoto Univ, Dept Oral & Maxillofacial Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan

关键词: Synovial fluid;    Mesenchymal stem cells;    Chondrogenesis;    Temporomandibular joint disorder;   

DOI  :  10.1016/j.lfs.2011.09.005

来源: Elsevier

【 摘 要 】

Aims: Mesenchymal stem cells are an interesting source of material for regenerative medicine. The present study aimed at characterizing the phenotype and differentiation potential of adherent synovial fluid-derived cells from temporomandibular joint (TMJ) disorder patients. Main methods: Synovial fluid collection takes place during TMJ cavity irrigation arthrocentesis under local anesthesia. The synovial fluid-derived adherent cells were fibroblast-like and spindle-shaped. Ex vivo-expanded synovial fluid-derived cells were shown to express STRO-1 and CD146, previously found to be present in bone marrow mesenchymal stem cells. Further, they were identified as being capable of differentiating into a variety of cell types including osteoblasts, chondrocytes, adipocytes, and neurons. Key findings: The present study demonstrates that human pluripotent cells can be isolated from synovial fluid. These synovial fluid-derived cells cannot only be derived from a very accessible resource, but are also capable of providing sufficient cells for potential clinical applications. Significance: These cells may play a role in the regenerative response during arthritic diseases and are promising candidates for developing novel cell-based therapeutic approaches for postnatal skeletal tissue repair. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.

【 授权许可】

Free