A lung for all: Novel mechanical ventilator for emergency and low-resource settings

LIFE SCIENCES

卷:257

Article

Zuckerberg, Jeremy¹  Shaik, Mohammed¹  Widmeier, Keith²  Kilbaugh, Todd³  Nelin, Timothy D.¹ 

[1] Childrens Hosp Philadelphia, Dept Pediat, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Ctr Simulat Adv Educ & Innovat, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Dept Anesthesia & Crit Care Med, Philadelphia, PA 19104 USA

关键词: Low-resource ventilator;    Respiratory;    Lungs;    COVID;    SARS-CoV-2;    Coronavirus;   

DOI  :  10.1016/j.lfs.2020.118113

来源: Elsevier

【 摘 要 】

Aims: To create a low-cost ventilator that could be constructed with readily-available hospital equipment for use in emergency or low-resource settings. Main methods: The novel ventilator consists of an inspiratory limb composed of an elastic flow-inflating bag encased within a non-compliant outer sheath and an expiratory limb composed of a series of two, one-way bidirectional splitter valves derived from a self-inflating bag system. An Arduino Uno microcontroller controls a solenoid valve that can be programmed to open and close to produce a set respiratory rate and inspiratory time. Using an ASL 5000 Lung Simulator, we obtained flow, pressure, and volume waveforms at different lung compliances. Key findings: At a static lung compliance of 50 mL/cm H2O and an airway resistance of 6 cm H2O/L/s, ventilated at a PIP and PEEP of 16 and 5 cm H2O, respectively, tidal volumes of approximately 540 mL were achieved. At a static lung compliance of 20 mL/cm H2O and an airway resistance of 6 cm H2O/L/s, ventilated at a PIP and PEEP of 38 and 15 cm H2O, respectively, tidal volumes of approximately 495 mL were achieved. Significance: This novel ventilator is able to safely and reliably ventilate patients with a range of pulmonary disease in a simulated setting. Opportunities exist to utilize our ventilator in emergency situations and low resource settings.

【 授权许可】

Free