When a TRP goes bad: Transient receptor potential channels in addiction

LIFE SCIENCES

卷:92

Review

Wescott, Seth A.^1,2  Rauthan, Manish⁴  Xu, X. Z. Shawn^1,2,3 

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Neurosci Grad Program, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[4] Univ Gothenburg, Dept Cellular & Mol Biol, S-41390 Gothenburg, Sweden

关键词: Drug;    Abuse;    Addiction;    Nicotine;    Cocaine;    Ethanol;    Behavior;    TRP;    Channel;    Nucleus accumbens;    Prefrontal cortex;    C. elegans;   

DOI  :  10.1016/j.lfs.2012.07.008

来源: Elsevier

【 摘 要 】

Drug addiction is a psychiatric disease state, wherein a drug is impulsively and compulsively self-administered despite negative consequences. This repeated administration results in permanent changes to nervous system physiology and architecture. The molecular pathways affected by addictive drugs are complex and inter-dependent on each other. Recently, various new proteins and protein families have been discovered to play a role in drug abuse. Emerging players in this phenomenon include TRP (Transient Receptor Potential) family channels, which are primarily known to function in sensory systems. Several TRP family channels identified in both vertebrates and invertebrates are involved in psychostimulant-induced plasticity, suggesting their involvement in drug dependence. This review summarizes various observations, both from studies in humans and other organisms, which support a role for these channels in the development of drug-related behaviors. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free