Current research trends and challenges in tissue engineering for mending broken hearts

LIFE SCIENCES

卷:229

Review

Qasim, Muhammad³  Arunkumar, Pala¹  Powell, Heather M.^4,5  Khan, Mahmood^1,2 

[1] Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Dept Emergency Med,Wexner Med Ctr, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Physiol & Cell Biol, Wexner Med Ctr, Columbus, OH 43210 USA

[3] Konkuk Univ, Humanized Pig Res Ctr SRC, Dept Stem Cell & Regenerat Biotechnol, Seoul, South Korea

[4] Ohio State Univ, Dept Mat Sci & Engn, Dept Biomed Engn, Columbus, OH 43210 USA

[5] Shriners Hosp Children, Res Dept, Cincinnati, OH USA

关键词: Stem cells;    Biomaterials;    Nanofibers;    Tissue engineering;    Hydrogels;    Drug screening;    Cardiac 3D printing;   

DOI  :  10.1016/j.lfs.2019.05.012

来源: Elsevier

【 摘 要 】

Cardiovascular disease (CVD) is among the leading causes of mortality worldwide. The shortage of donor hearts to treat end-stage heart failure patients is a critical problem. An average of 3500 heart transplant surgeries are performed globally, half of these transplants are performed in the US alone. Stem cell therapy is growing rapidly as an alternative strategy to repair or replace the damaged heart tissue after a myocardial infarction (MI). Nevertheless, the relatively poor survival of the stem cells in the ischemic heart is a major challenge to the therapeutic efficacy of stem-cell transplantation. Recent advancements in tissue engineering offer novel biomaterials and innovative technologies to improve upon the survival of stem cells as well as to repair the damaged heart tissue following a myocardial infarction (MI). However, there are several limitations in tissue engineering technologies to develop a fully functional, beating cardiac tissue. Therefore, the main goal of this review article is to address the current advancements and barriers in cardiac tissue engineering to augment the survival and retention of stem cells in the ischemic heart.

【 授权许可】

Free