Comparison between simulation and experimentally observed interactions between two magnetic beads in a fluidic system

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:407

Article

Oduwole, Olayinka¹  Grob, David Tim¹  Sheard, Steve¹ 

[1] Univ Oxford, Dept Engn Sci, Parks Rd, Oxford OX1 3PJ, England

关键词: Super-paramagnetic bead;    Magnetic separation;    Magnetic interaction;    Hydrodynamic interaction;    Microfluidics;    Magnetic field;   

DOI  :  10.1016/j.jmmm.2016.01.043

来源: Elsevier

【 摘 要 】

Continuous flow separation of magnetic particles within a microfluidic device could lead to improved performance of magnetic bead-based assays but the undesirable formation of bead clusters reduces its efficiency; this efficiency refers to the ability to separate bound magnetic beads from a mixture of particles. Such agglomerates are formed due to magnetic binding forces while hydrodynamic interactions strongly influence the particles' movement. This paper presents a model for interactions between a pair of equal sized super-paramagnetic beads suspended in water within a uniform magnetic field. To the best of our knowledge, we present for the first time a comparison between simulated trajectories and the beads' movement captured on video; the beads were suspended in a stationary fluid placed within a uniform magnetic field. In conclusion, the model is a good approximation for beads interacting with their nearest neighbours and is able to predict the trajectory pattern of these particles in a magnetic bead based assay. Predicting the magnetically induced interaction of nearby beads will help in determining the density of beads in an assay and in avoiding agglomeration over a fixed time duration. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free