Magnetic and in vitro heating properties of implants formed in situ from injectable formulations and containing superparamagnetic iron oxide nanoparticles (SPIONs) embedded in silica microparticles for magnetically induced local hyperthermia

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:323

Article

Le Renard, Pol-Edern¹  Lortz, Rolf²  Senatore, Carmine^3,4  Rapin, Jean-Philippe⁵  Buchegger, Franz^6,7  Petri-Fink, Alke⁸  Hofmann, Heinrich⁹  Doelker, Eric¹  Jordan, Olivier¹ 

[1] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, Geneva, Switzerland

[2] Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China

[3] Univ Geneva, Dept Condensed Matter Phys, Geneva, Switzerland

[4] Univ Geneva, MaNEP NCCR, Geneva, Switzerland

[5] Univ Geneva, Crystallog Lab, Geneva, Switzerland

[6] Univ Lausanne Hosp, Nucl Med Serv, Lausanne, Switzerland

[7] Univ Hosp Geneva, Geneva, Switzerland

[8] Univ Fribourg, Dept Chem, CH-1700 Fribourg, Switzerland

[9] Ecole Polytech Fed Lausanne, Lab Powder Technol, Lausanne, Switzerland

关键词: Magnetically mediated hyperthermia;    Superparamagnetism;    SPIONS;    Microparticles;    Composite magnetic microparticles;    Injectable formulations;    In situ forming implant;    Magnetic properties;    SQUID;    Heating;    AMF;    Specific power loss;    Calorimetry;    Pycnometry;    Laser diffraction;    DFX;    TEM;    SEM;   

DOI  :  10.1016/j.jmmm.2010.12.003

来源: Elsevier

【 摘 要 】

The biological and therapeutic responses to hyperthermia, when it is envisaged as an anti-tumor treatment modality, are complex and variable. Heat delivery plays a critical role and is counteracted by more or less efficient body cooling, which is largely mediated by blood flow. In the case of magnetically mediated modality, the delivery of the magnetic particles, most often superparamagnetic iron oxide nanoparticles (SPIONs), is also critically involved. We focus here on the magnetic characterization of two injectable formulations able to gel in situ and entrap silica microparticles embedding SPIONs. These formulations have previously shown suitable syringeability and intratumoral distribution in vivo. The first formulation is based on alginate, and the second on a poly(ethylene-co-vinyl alcohol) (EVAL). Here we investigated the magnetic properties and heating capacities in an alternating magnetic field (141 kHz, 12 mT) for implants with increasing concentrations of magnetic microparticles. We found that the magnetic properties of the magnetic microparticles were preserved using the formulation and in the wet implant at 37 degrees C, as in vivo. Using two orthogonal methods, a common SLP (20 Wg(-1)) was found after weighting by magnetic microparticle fraction, suggesting that both formulations are able to properly carry the magnetic microparticles in situ while preserving their magnetic properties and heating capacities. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

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